Ability Cooldown Displayīy default, skill cooldowns are only shown in seconds. With Show Spell costs you can now see the exact mana or energy costs of your abilities. The activation of the spell cost display is missing here. The Minimap Scale, on the other hand, should be definitely enlarged a little, because it gives you important information about the movement of opponents and spawn timers of camps and epic monsters. These two aren't that important and just take away your view of the battlefield. The HUD-and Chat-scaling can be turned down a bit. The default settings for the interface are not ideal, so you should adjust them a little. This makes it very easy to reach with the left hand.
But since that is extremely far to the right on the keyboard, I have placed the shop on the Y-key as an alternative. By using this ping, you can help your jungler enormously, even if you are not using the chat. With this ping you signal to your team where the opponent has put his wards. Therefore it can only be found in the options and not in the "ping wheel".
This ping is the only one that has been added since the game was released. Personally, I put Player Attack Move Click on the A-button. If you like to play Kalista, this option is an absolute must if you don't want to get sore fingers from clicking while playing.
With this, your champion will go and shoot auto attacks on anything that gets in his way. How many times has it happened to you that you attacked a minion or a ward instead of the enemy champion? With Target Champions Only, this will no longer happen. You should definitely assign this setting to a key that you can reach easily. However, some of them are not yet optimal and should therefore be adjusted by you as soon as possible. New League of Legends accounts all have the same default settings.